Worldwide, the neurological disorders are affecting a great number of patients, lowering their quality of life. Stem cell-based therapies have been applied but still need further optimization. MSCs could be used in neurological disorders via differentiation to neurallike cells. The main objectives of this study were to determine the expression of CD271 in WJ-MSCs and then to differentiate them into neural-like cells, with a combination of bFGF and forskolin. The results clearly showed the expression of CD271 and the successful differentiation of WJ-MSCs into neurallike cells that can be used for personalized medicine in patients with neurological disorders.
Panagiotis Mallis, Gregory Papadopoulos, Efstathios Michalopoulos, Catherine Stavropoulos-Giokas