The present investigation is to assess the antiulcer activity by utilizing natural remedy Lagenaria siceraria. The chloroform extract of Lagenaria siceraria treated groups demonstrates a huge impact when related to controller group animals. The acute toxicity study for chloroform extract of Lagenaria siceraria indicates that, it is harmless till 400 mg/kg body weight. The chloroform extract of Lagenaria siceraria at 250 mg/ kg dose has shown mucosal erosion, the partial healing of ulcer with few inflammatory cells and the dose 400 mg/kg has shown healing ulcer, mucosa and no inflammation of cells. Lagenaria siceraria extracts reported to own antioxidant activity and to contain various types of compounds such as flavonoids, saponins and tannins. The gastro protective effect exhibited by chloroform extract Lagenaria siceraria is speculated to be recognized for its antioxidant property, which in turn could be linked to existence of flavonoids and polyphenolic compounds, saponins and tannins. These compounds most likely inhibit gastric mucosal injury. The chloroform extract of Lagenaria siceraria treated groups illustrate a major effect when related to control group animals which shows that the plant containing antiulcer action.