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Abstract

Effects of Aqueous Extract of Bridelia ferruginea Benth on the Kinetic of Water Overload Elimination in Normal Rat

The effects of an aqueous extract of Bridelia ferruginea stem-bark (SEA) have been evaluated on on the elimination of the water overlaod in male rat. The experiments were carried out under the same conditions with synthetic pharmacological diuretics (furosemide, hydrochlorothiazide, and spironolactone). The parameter which was taken account during the experimentation was total urine volume. The aqueous extract of Bridelia ferruginea, 24 hours after its administration intraperitoneally in the rat, involves a significant (p?0.01) urine output compared to control. This study demonstrated a dose-dependent increase in diuresis in animal treated with Bridelia ferruginea extract. The effect of SEA tends toward those of furosemide. These results seem to justify its use in traditional medicine as diuretic.


Author(s): Semi Anthelme NENE-Bi, Tianga Yaya SORO, Ouga Stanislas ZAHOUI, Gomé Michel BLEU, NDouffou Célestin EHOUSSOU, Flavien TRAORE

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