The leaves, stem and root barks Khaya senegalensis (Desv.) A.Juss were evaluated for polyphenol composition and antioxidant properties. The identifiable phenolics in the leaf extract of Khaya senegalensis include catechin, rutin and quercetin rhamnoside, while the stem barks contain catechin and procyanidins. Using the hypoxanthine/xanthine assay model, the plant displayed antioxidant potential with IC50 values of 46, 37 and 64 μl for the leaves, stem bark and roots, respectively. Using the 2-deoxyguanosine assay model system the leaves, stem bark and roots showed radical scavenging capacity with IC50 values of 178, 91 and 122 μl, respectively. These observed activities are therapeutically relevant in Nigeria where the plant is part of herbal recipes in treating diseases with oxidative stress as a major etiological factor.