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17 β-estradiol induced oxidative stress in gill, brain, liver, kidney and blood of common carp (Cyprinus carpio)

Title 17 β-estradiol-induced oxidative stress in gill, brain, liver, kidney and blood of common carp (Cyprinus carpio)

Background Endocrine-disrupting chemicals are of great public and scientific concern, since these chemicals can mimic, block, or interfere with hormones in the body and can subsequently induce detrimental effects on reproductive processes in wildlife and in humans. Estrogenic compounds such as 17 β-estradiol can reach the aquatic environment because wastewater treatment plants are not sufficiently effective in reducing and/or removing these contaminants, damaging the organisms living there. This study aimed to evaluate the oxidative stress induced by 17 β-estradiol in gill, brain, liver, kidney and blood of C. carpio.

Methods and Findings Carp were exposed at environmentally relevant concentrations (1 ng L-1, 1 ?g L-1 and 1 mg L-1) for different exposure periods (12, 24, 48, 72 and 96 h), and the following biomarkers were evaluated: hydroperoxide content (HPC), lipid peroxidation (LPX), protein carbonyl content (PCC), and the activity of the antioxidant enzymes superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPx). Statistically significant increases with respect to the control group (P<0.05) were observed in HPC, LPX and PCC at all concentrations particularly in kidney and blood of exposed specimens. SOD, CAT and GPx activity also increased at all concentrations in the same organs with respect to the control group.

Conclusion The estrogenic compound 17 &#946;-estradiol induce oxidative stress in common carp (Cyprinus carpio).


Adriana Andrea Gutiérrez-Gómez, Nely San Juan-Reyes, Marcela Galar-Martínez, Octavio Dublán-García, Hariz Islas-Flores, Sandra García-Medina, Itzayana Pérez-Alvárez, Leobardo Manuel Gómez-Oliván

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