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Zn2+ with Clofibric Acid: A Peroxisome Proliferator-Activated Receptors-Alpha (PPARα) Ligand

Peroxisome proliferator-Activated Receptors-Alpha (PPARα) ligands are numerous. One such ligand is Clofibric Acid (CA). CA has a chemical structure that has the 2-phenoxy-2-methylpropanoic acid feature. This feature has the right chelation size to bind many metal ions such as Fe3+, Cr3+, Cu2+ and Zn2+. Using potentiometry and spectroscopy, we have found that CA chelates the first member of metal ions of group number 12 in the periodic table (i.e., Zn2+). This chelation occurred in aqueous media in 0.1 M NaNO3 at 25oC. The concentration of Zn2+=2.0 milli molar (2.0 mM). It appeared that, the molar extinction coefficient λmax of free CA is equal to 950 ± 9 M-1cm-1 compared to that of 1756 ± 61 M-1cm-1 for the Zn/CA complex in 1:1 ratio. Further confirmation using IR spectroscopy for the chelation of Zn2+ occurred in the solid phase. In this special issue of Electronic Journal of Biology (eJBio), we have presented two reports for the reaction of the ferric metal ion with CA.


Yahia Z Hamada, Aisha Darboe

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