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The Use of Concentrated Growth Factors and Autogenous Bone for Periodontal Soft Tissue Augmentation and Bone Regeneration: A Case Report

Objective: To achieve periodontal soft tissue and bone augmentation using concentrated growth factors (CGFs) and autogenous bone in a single operation. Methods: A patient who presented with a thin gingival biotype and severe labial alveolar bone defect of the mandibular anterior teeth required orthognathic surgery. CGF and autogenous bone were used to achieve periodontal soft tissue and bone augmentation during the orthognathic surgery. Photos of the operative area were taken preoperatively and 12 days, 1, 3, 6 and 12 months after surgery to evaluate the esthetic effect of periodontal soft tissue augmentation. The operative area was scanned using cone-beam computed tomography, in order to measure augmentation of the alveolar bone before and at 3, 6 and 12 months after surgery. Results: CGF treatment resulted in marked vascularization on the 12th day after the surgery. During the 12 months clinical follow-up, intraoral examinations showed that the periodontal soft tissue maintained complete root coverage and the increased gingival thickness remained stable. The color, shape and texture of CGF-treated region gradually became similar to that of the surrounding gingiva, achieving a satisfying esthetic effect. Moreover, cone-beam computed tomography showed that the labial alveolar bone of the mandibular anterior teeth was also augmented in height and thickness, which gradually stabilized in the 6th month after surgery. Conclusion: CGF combined with autogenous bone can achieve periodontal soft tissue and bone augmentation. A 12 months follow-up period revealed stable augmentation and a satisfying esthetic effect.


Xuan Ying, Yue Chen*, Ning Luo, Lei Shi, Yuxin Tong, Jiayu Zhang

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