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The Effect of Erythropoietin on Aspartate Aminotransferase Levels during Ischemia Reperfusion Injury in Rats.

Objective: This experimental study examined the effect of erythropoietin (Epo) on rat model and particularly in a liver ischemia-reperfusion (IR) protocol. The effect of that molecule was studied biochemically using blood mean aspartate aminotransferase (AST) levels.
Materials and methods: The 40 rats of mean weight 247.7 g were used in the study. AST levels were measured at 60 min (groups A and C) and at 120 min (groups B and D) of reperfusion. Epo was administered only in groups C and D.
Results: Epo administration kept significantly increased the AST levels by 26.71% ± 13.17% (p=0.0235). Reperfusion time kept significantly increased the AST levels by 27.58% ± 13.12% (p=0.0271). Along, Epo administration and reperfusion time together produced a significant combined effect in keeping increased the AST levels by 19.73% ± 7.70% (p=0.0119).
Conclusions: Epo declined the difference of elevated post-IR values from the sham AST values, from significant level after 1.5 h reperfusion at nonsignificant level after 2 h reperfusion. So, Epo was proved an optimal resolving factor for liver IR injury after 1.5 h reperfusion.


C. Τsompos, C. Panoulis, K Τοutouzas, A. Triantafyllou, G. Ζografos, A. Papalois

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