Electronic Journal of Biology

Significance of the Expression of CD 90, 96, 117 and 123 in Egyptian Patients with Acute Myeloid Leukemia, Relation to Prognosis and Response to Treatment

Objective: Investigating the expression pattern of CD 90, 96,117 and 123 in bone marrow or peripheral blood from adult patients with acute myeloid leukemia and their use as markers for diagnosis and prognosis. Patients and methods: Using Muli-color flowcytometry, we analyzed the expression of CD90, 96, 117 and 123 among [CD34+/CD38-] cell population in AML patients at initial diagnosis. Results: It was found that percentage of CD90+ cells was lower among [CD34+/CD38-] cells in of AML cases than control group, however this difference didn't reach any statistical significance (p value=0.06), the percentage of CD96+ cells among CD34+CD38- cells was higher in AML cases than for control group (that show a highly statistically significant difference (p value<0.001), the percentage of CD117 cells was higher among CD34+ CD38- cells in AML cases than for control group, however this difference didn't show statistical significance (p value=0.079), While percentage of CD123 was significantly higher among [CD34+/CD38-] cells in AML cases than the control group and this difference shows a high statistical significance (P value<0.001).

Author(s):

Sahar K Hussein, Ahmed A Shams El Deen, Nohair Soliman, Kareeman G Mohammed, Marwa T Ashour, Noha Y Ibrahim, Ahmed A Mohammed, Aml S Nasr

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