Reach Us Animal research and nutrition, animal nutrition, livestock, animal husbandry, animal feed, cattle feeding and domestication feed additive, food chain +44 118 315 0749


Molecular Docking Studies of Anthraquinone Derivatives on the Crystal Structure of Glycogen Synthase Kinase 3 Beta

Glycogen synthase kinase 3β (GSK3β) is a serine/threonine kinase that has enzymatic activity regulated by many signaling pathways and by distinct multiproteincomplexes. Glycogen synthase kinase-3β (GSK-3β) has been investigated for its potential binding affinity with selective anthraquinones like aesculin, aesculetin, anthragallol, damnacanthal, lucidin, morindone, nordamnacanthal and Rubiadin. Insilico docking studies showed that almost every ligands with better binding affinity and a satisfactory inhibition constant. Among them damnacanthal, nordamnacanthal, Anthragallol and morindone showed lowest free energy of binding through interaction with potential areas of amino acids exposed at the active site crucial for enzyme inhibition. These ligands can be targeted towards the inhibition of Glycogen synthase kinase-3β (GSK-3β) involved in specific neoplastic disoders like prostate cancer, oral cancer etc.

Author(s): Karthik Dhananjayan, Sumathy Arunachalam, Palanisamy Sivanandy

Abstract | Full-Text | PDF

Share this  Facebook  Twitter  LinkedIn  Google+
17+ Million Readerbase
Google scholar citation report
Citations : 3582

Electronic Journal of Biology received 3582 citations as per google scholar report

Electronic Journal of Biology peer review process verified at publons
Abstracted/Indexed in
  • Google Scholar
  • China National Knowledge Infrastructure (CNKI)
  • CiteFactor
  • Electronic Journals Library
  • Zoological Records
  • WorldCat
  • Proquest Summons
  • Publons
  • MIAR
  • Secret Search Engine Labs

View More »

Flyer image