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Molecular Detection of HCMV and Investigation of Its Relationship with Quality of Sperm Parameters in Male Infertility

Background Infertility is the inability of a couple to conceive (irrespective of causes) after one year of consecutive sexual intercourse using no birth control methods. Men are responsible for infertility in 50% of infertile spouses. Numerous factors contribute to male infertility including genital infections that may appear following microbial, fungal, and viral infections. The present study aims to identify HCMV DNA in the semen of infertile men admitted to Infertility clinic as an infertility risk factor in couples.

Material and Finding In this study, 50 semen samples of fertile men (as the control group) and 50 semen samples of infertile men were collected from Infertility Center of Qom Jihad Daneshgahi, Qom, Iran. The semen samples were analyzed according to World Health Organization’s standard methods and cytomegalovirus was detected using nested polymerase chain reaction technique. The analyzed spermogram of 50 infertile samples showed that 36%, 68%, and 72% of the samples had problems, respectively in terms of count, motility, and morphology, and 52% of the infertile samples had problems in all three parameters. Human cytomegalovirus DNA was detected in three and two samples of infertile and fertile men respectively. The results were analyzed using SPSS (version 14.1) software with a significance level of P<0.05.

Conclusions According to statistical analysis no significant correlation was obtained between the cytomegalovirus infection and male infertility. Although the results achieved may vary with changes in population size.


Khatereh Baghdadi, FarzanehTafvizi, Nasim Hayati Roodbari

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