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Abstract

Homology model of 2C-methyl-d-erythritol 2, 4- cyclodiphosphate (MECP) synthase of Plasmodium falciparum 3D7

Malaria has been a cause of enormous morbidity and mortality since the dawn of evolution. Control of malaria remains a farfetched dream despite numerous efforts and intervention strategies devised by research communities. Increasing drug resistance in the malarial parasite to conventional drugs has raised an alarm. This situation warrants the need for exploring novel drug targets. In this study, we report the structural modeling of an attractive drug target 2C-methyl-d-erythritol 2, 4- cyclodiphosphate (MECP) synthase. Threedimensional model of the enzyme was constructed using in-silico tools. The model was further evaluated for stereo-chemical quality. This model will provide an insight about the structure of MECP synthase and aid in rational drug design


Author(s): Neelima Arora, Amit Kumar Banerjee, U.S.N Murty

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