This study aimed to investigate positive thinking skills on mental health, self-esteem of university's students in Torbat-e Jam city. The research population included all of students in University of Torbat-e Jam and sample of 30 students who were selected randomly in experimental and control groups. The instruments used in this study are Goldberg's General Health Questionnaire, Self Esteem Scale and guide positive thinking skills. Research design was pretest, posttest with control group. After random selection of experimental and control groups, pre-test were conducted on two groups, experimental intervention (positive thinking skills) were carried out after training and both groups were assessed. The results show that positive thinking skills increase self-esteem and mental health of students in the experimental group compared with control.