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As2O3 Induces Oxidative Stress in Gill, Liver, Brain and Blood of Cyprinus carpio

Background Arsenic (As) is a toxic trace element for diverse aquatic species. It is present naturally in water in diverse oxidation states and chemical species. During its biotransformation, As induces production of reactive oxygen species, eliciting oxidative stress in diverse organisms. This study aimed to evaluate As-induced toxicity in brain, liver, blood and gill of the common carp Cyprinus carpio.

Methods and Findings The following biomarkers were using to determine oxidative stress: hydroperoxide content, lipid peroxidation, protein carbonyl content and the antioxidant activity of the enzymes superoxide dismutase, catalase and glutathione peroxidase. Bioconcentration factor was analyzed. Exposure to 0.05 mg As2O3 L-1 induced changes in biomarkers of oxidative stress as well as antioxidant activity in all tissues evaluated (P<0.05), this damage being most evident in liver. BCF levels were higher on gill.

Conclusions The biomarkers used in this study are useful for early detection of As-induced toxicity in fish.


Luis Gerardo Bernadac-Villegas, Dora Alicia Solís-Casados, Alba Yadira Corral-Avitia, Marcela Galar-Martínez, Hariz Islas-Flores, Octavio Dublán-García, Leobardo Manuel Gómez-Oliván

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