Different extracts of Moringa oleifera parts were evaluated for their anti-trypanosomal activity and broad phytochemical classes. Alkaloids, resins and saponins were detected. In vitro, the petroleum ether extract of the root bark, chloroform extract of the stem bark, methanol extracts of the stem and the aqueous extracts of all parts were active at 4 and 2 mg/ ml doses. The chloroform and methanol extracts of the leaves, and the chloroform extract of the root also possessed strong activity. In vivo, methanol and aqueous extracts of the leaves, stem and root barks at 300mg/kg displayed significant effect on parasitaemia and survival period, indicating their anti-trypanonosomal potential.