The toxicity problems caused by those of synthetic origin pigments to the environment have created a mounting interest towards natural pigments. Among natural pigments, pigments from microbial sources are potentially good alternative ones to synthetic pigments. Prodigiosin, the bright red pigment produced by organisms of the genus Serratia, is among the more conspicuous pigments extant in the microbial world. The chemical nature of prodigiosin continues to be the subject of extensive study and it has been defined as a tri-pyrrylmethene. The rather rapid production of a flashy red pigment, which did not escape the observation of men before they had any inkling of the nature of microbial growth, can now is understood in terms of prodigiosin production. The prodigiosin pigments have intrigued organic chemists and pharmacologists and may yet play roles in the treatment of infectious diseases such as malaria and as immunosuppressant agents. However, a major reason for much of the continuing curiosity in the prodigiosin / Serratia story is the theory that these viscous, crimson bacterial colonies provide a naturalistic explanation. This review article highlights the characteristics and potential of prodigiosin pigment from Serratia.