Reach Us +1 218 451 2974

Abstract

Stem Cell Transplantation Combined with Niche Modification: A Novel Strategy for Treatment of Neurodegeneration

Stem cells are self-renewable and multipotent, and exist in various tissues including fetal brains. There is a growing knowledge of how stem cells differentiate into mature cells and how the niche, a microenvironment surrounding stem cells, regulates their proliferation and differentiation. Consequently, establishment of a cell replacement therapy to treat many neurological disorders that are presently incurable is strongly anticipated. In this report, we present a survey of experimental trials of treatment using neural stem cells in animal models of various neurological disorders such as Parkinson’s disease (PD), multiple sclerosis, stroke, spinal cord injury, and perinatal hypoxia-ischemia. In some of these trials, neural stem cells were transplanted in combination with modulation of the extracellular matrix of host tissues. Although many problems remain to be solved in advance of clinical use, stem cell transplantation combined with niche modulation could be a novel strategy for treatment of various neurological disorders.


Author(s): Keiko Nakanishi, Atsuhiko Oohira

Abstract | Full-Text | PDF

Share this  Facebook  Twitter  LinkedIn  Google+
30+ Million Readerbase
Flyer image
Abstracted/Indexed in
  • Index Copernicus
  • Google Scholar
  • China National Knowledge Infrastructure (CNKI)
  • CiteFactor
  • Electronic Journals Library
  • Zoological Records
  • WorldCat
  • Proquest Summons
  • Publons
  • MIAR
  • Open Access Journals Search Engine (OAJSE)
  • Openaccessarticles.com
  • Secret Search Engine Labs