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Antioxidants: Novel Approach to ROS Sensitive TRP Channels Gating Manner

Reactive Oxygen Species (ROS) trigger oxidative stress conditions which leads cellular damage. Oxidative stress is the unbalanced situation in favour to the oxidants. Free oxygen radicals, in unstable conditions, may function as signal transduction molecules. Transient Receptor Potential (TRP) channels, as Ca2+- permeable cation channels, that sense environmental changes, such as pH, temperature, chemical, etc. TRP channels attract scientist’s interest due to their vital role in cellular mechanisms, such as apoptosis, neural functions. The members of one subgroup of TRP channels have appeared as ROS sensors. The importance of antioxidants on Ca2+ signalling mechanisms, induced by the activation of ROS-sensitive TRP channels, under pathological conditions is still unclear. In the current mini-review, we aimed to summarize the importance of the antioxidants and their vital role on TRP channel activity. ROS-sensitive TRP channels poses extremely important role for future challenge which may lead to investigation and/or strategy to develop new therapeutic agents for the suppression and/or activation of ROS-related diseases.


Ahmi ÖZ, Ömer Çelik, Bejarano I, Abdülhadi Cihangir Uğuz

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