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Abstract

Study of Oxidative Stress Parameters in Patients with Hyperthyroidism

In South Asian population, thyroid disorders are highly prevailing due to iodine deficiency and goitrogen use. In Pakistan, There are more common thyroid diseases in male as compared to female. Graves’s disease is an autoimmune disorder and it accounts for 70-80% of all cases of hyperthyroidism. Hyperthyroidism denotes to over production of thyroid hormones and increased speed of basal metabolism, instigated by increased total consumption of oxygen which leads to increase formation of reactive oxygen species. Reactive oxygen species are one of the main causes of oxidative stress in hyperthyroidism. The aim of this study was the analyses of the oxidative stress parameters in hyperthyroid patients by the analysis of reactive oxygen species which are involved in neutralizing the activity of enzymes such as Superoxide Dismutase (SOD), Catalase (CAT), Glutathione (GSH) and by the quantification of RBCs total antioxidant status. In this study, fifty patient samples with diagnosed hyperthyroidism were included in this study. The levels of Superoxide Dismutase (SOD), Catalase (CAT) and Glutathione (GSH) were measured. The control group consisted of 10 persons in whom serum Thyroid Stimulating Hormone (TSH) were within the normal range. Patients with hyperthyroidism compared with healthy patients were characterized by an increased level of SOD and CAT in female patients as compared to male patients and control groups while the level of GSH remains same for all included groups. It was concluded that hyperthyroidism state in patients is due to production of free radicals formation and disturbance in antioxidant balance which increased significantly as compared to control group.


Author(s):

Imran Riaz Malik*, Uzair Ahmad Raza, Muhammad Yasin, Ahmad Zaheer, Arif Malik and Rabail Alam



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